Publications 2010

(74) E. Freisinger* (2010).
The metal-thiolate clusters of plant metallothioneins.
Chimia 64, 217-224 (DOI: 10.2533/chimia.2010.1).

Publications 2009

(73) S. Muhammad*, G. Murtaza, E. Freisinger, M. K. Rauf & A. Saeed (2009).
(Z)-2-Phenyl-3-pivaloyl-1,1-dipropylguanidine.
Acta Cryst. E65, o2073-o2074 (DOI: 10.1107/S160053680902978X).

(72) X. Wan & E. Freisinger* (2009).
The plant metallothionein 2 from Cicer arietinum forms a single metal-thiolate cluster.
Metallomics 1, 489-500 (DOI: 10.1039/B906428a).

(71) E. A. Peroza, R. Schmucki, P. Güntert, E. Freisinger* & O. Zerbe* (2009).
The ßE-domain of wheat Ec-1 metallothionein: A metal-binding domain with a distinctive structure.
J. Mol. Biol. 387, 207-218 (DOI: 10.1016/j.jmb.2009.01.035).

(70) E. Freisinger* (2009).
Metallothioneins in plants.
Met. Ions Life Sci. 5, 107-153 (DOI: 10.1039/9781847558992-00107).

(69) E. A. Peroza, A. Al Kaabi, W. Meyer-Klaucke, G. Wellenreuther & E. Freisinger* (2009).
The two distinctive metal ion binding domains of the wheat metallothionein Ec-1.
J. Inorg. Biochem. 103, 342-353 (DOI: 10.1016/j.jinorgbio.2008.11.008).

(68) Invited Publication: Protagonists in Chemistry: Bernhard Lippert
O. Schicht & E. Freisinger* (2009).
Spectroscopic characterization of Cicer arietinum metallothionein 1.
Inorg. Chim. Acta 362, 714-724 (DOI: 10.1016/J.ica.2008.03.097).

Publications 2008

(67) E. Freisinger* (2008).
Plant MTs—long neglected members of the metallothionein superfamily.
Dalton Trans., 6663-6675 (DOI: 10.1039/b809789e).

(66) E. Freisinger*, R. Griesser, B. Lippert, C. F. Moreno-Luque, J. Niclós-Gutiérrez, J. Ochocki, B. P. Operschall & H. Sigel* (2008).
Comparison of the surprising metal ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(iso-propyl) esters of H2(6Umpa).
Chem. Eur. J. 14, 10036-10046 (DOI: 10.1002/chem.200800998).

(65) W.-Z. Shen, R.-D. Schnebeck, E. Freisinger & B. Lippert* (2008).
On the interrelationship of μ-OH bridged dimers, trimers, and tetramers of (en)PtII and their Ag+ adducts.
Dalton Trans., 4044-4049 (DOI: 10.1039/b802924e).

(64) E. A. Peroza & E. Freisinger* (2008).
Tris is a non-innocent buffer during intein-mediated protein cleavage.
Protein Expres. Purif. 57, 217-225 (DOI: 10.1016/j.pep.2007.10.003).

(63) J. Müller*, F.-A. Polonius, E. Freisinger & E. G. Bardajía (2008).
X-ray crystallographic study of several 2´-deoxy-β-D-ribonucleosides with 1-deazapurine-derived aglycones.
Carbohyd. Res. 343, 397-403 (DOI: 10.1016/j.carres.2007.11.007).

Publications 2007

(62) E. Gil Bardaji, E. Freisinger*, B. Costisella, C. A. Schalley, W. Brüning, M. Sabat & B. Lippert* (2007).
Mixed-metal (platinum, palladium), mixed-pyrimidine (uracil, cytosine) self-assembling metallacalix[n]arenes:
Dynamic combinatorial chemistry with nucleobases and metal species.
Chem. Eur. J. 13, 6019-6039 (DOI: 10.1002/chem.200601529).

(61) E. Freisinger & R. K. O. Sigel* (2007).
From nucleotides to ribozymes - a comparison of their metal ion binding properties.
Coord. Chem. Rev. 251, 1834-1851 (DOI: 10.1016/j.ccr.2007.03.008).

(60) E. A. Peroza & E. Freisinger* (2007).
Metal ion binding properties of Triticum aestivum Ec-1 metallothionein:
Evidence supporting two separate metal-thiolate clusters.
J. Biol. Inorg. Chem. 12, 377-391 (DOI: 10.1007/s00775-006-0195-5).

(59) Invited Publication: Inorganic Chemistry - The Next Generation
E. Freisinger* (2007).
Spectroscopic characterization of a fruit-specific metallothionein: M. acuminata MT3.
Inorg. Chim. Acta 360, 369-380 (DOI: 10.1016/j.ica.2006.07.059).

(58) Invited Publication: Inorganic Chemistry - The Next Generation
S. Gallo, E. Freisinger & R. K. O. Sigel* (2007).
Towards the synthesis of light-stable cofactor B12 analogs.
Inorg. Chim. Acta 360, 360-368 (DOI: 10.1016/j.ica.2006.07.103).

(57) Invited Publication: Inorganic Chemistry - The Next Generation
J. Müller*, E. Freisinger, P. Lax, D. A. Megger & F.-A. Polonius (2007).
Interaction of Pt(II) and Pd(II) complexes of terpyridine with 1-methylazoles: A combined experimental and density functional study.
Inorg. Chim. Acta 360, 255-263 (DOI: 10.1016/j.ica.2006.07.031).

Publications 2006

(56) M. Willermann, C. Mulcahy, R. K. O. Sigel, M. Morell Cerdà, E. Freisinger, P. J. Sanz Miguel, M. Roitzsch & B. Lippert* (2006).
Pyrazine as a building block for molecular architectures with PtII.
Inorg. Chem. 45, 2093-2099 (DOI: 10.1021/ic051966k).

Publications 2005

(55) J. Müller* & E. Freisinger (2005).
[(1-Methylcytosine)2H]I, an asymmetric base pair.
Acta Cryst. E61, o320-o322.

Publications 2004

(54) E. Freisinger, A. P. Grollman, H. Miller & C. Kisker* (2004).
Lesion (in)tolerance reveals insights into DNA replication fidelity.
EMBO J. 23, 1494–1505.

Publications 2003

(53) E. Freisinger, I. B. Rother, M.-S. Lüth & B. Lippert* (2003).
Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII:
Artificial nucleobase quartets and C-H…N bonds.
Proc. Natl. Acad. Sci. USA 100, 3748-3753.

(52) E. Freisinger, A. Fernandes, A. P. Grollman & C. Kisker* (2003).
Crystallographic characterization of an exocyclic DNA adduct: 3, N4-etheno-2'-deoxycytidine in the dodecamer 5'-CGCGAATT(ethenoC)GCG-3'.
J. Mol. Biol. 329, 685-697.

(51) B. Beck, A. Schneider, E. Freisinger, D. Holthenrich, A. Erxleben, A. Albinati, E. Zangrando, L. Randaccio & B. Lippert* (2003).
Inter- and intra-molecular condensation patterns of (en)PdII with trans-[a2PtL2]2+ (a = am(m)ine, L = 2-aminopyridine):
PtPd3 and Pt2Pd4 species with multiple amide bridges. Unexpected trapping of a pair of nitrate ions by a Pt2Pd4 double cone.
Dalton Trans., 2533-2539.

(50) J. Müller, E. Freisinger, Pablo J. Sanz Miguel & B. Lippert* (2003).
Diplatinum(III) complexes with four bridging 1-methylcytosinato nucleobases derived from a mononuclear trans-(NH3)2PtII complex and CuII.
Inorg. Chem. 42, 5117-5125.

Publications 2002

(49) G. B. Onoa, V. Moreno, E. Freisinger & B. Lippert (2002).
Pd(II)- and Pt(II)-cimetidine complexes. Crystal structure of trans-[Pt(N,S-cimetidine)2]Cl2*12H2O.
J. Inorg. Biochem. 89, 237-247.

(48) G. Kampf, M. Willermann, E. Freisinger & B. Lippert (2002).
Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including guanine nucleobases.
Inorg. Chim. Acta 330, 179-188.

(47) W. Brüning, E. Freisinger, M. Sabat, R. K. O. Sigel & B. Lippert (2002).
N1 and N3 linkage isomers of neutral and deprotonated cytosine with trans-(CH3NH2)2PtII.
Chem. Eur. J. 8, 4681-4692.

(46) X. Riera, V. Moreno, E. Freisinger & B. Lippert (2002).
Pd(II) and Pt(II) (R,S)-3-aminopyrrolidine complexes. Reaction with 9-ethylguanine and study of their antiproliferative activity.
Inorg. Chim. Acta 339, 253-264.

(45) R. K. O. Sigel, E. Freisinger, M. Abbate & B. Lippert (2002).
Hydrogen bonding patterns of 7,9-dimethylguanine and its trans-platinum(II) complexes.
Inorg. Chim. Acta 339, 355-365.

(44) W. Brüning, I. Ascaso, E. Freisinger, M. Sabat & B. Lippert (2002).
Metal-stabilized rare tautomers of nucleobases. 8. Promotion of rare cytosine tautomer upon complex formation with (dien)M2+ (M = Pt, Pd).
Inorg. Chim. Acta 339, 400-410.


Publications 2001

(43) E. Freisinger, A. Schimanski & B. Lippert (2001).
Thymine-metal ion interactions: Relevance for thymine quartet structures.
J. Biol. Inorg. Chem. 6, 378-389.

(42) R. K. O. Sigel, S. M. Thompson, E. Freisinger, F. Glahé & B. Lippert (2001).
Metal-modified nucleobase sextet: Joining four linear metal fragments (trans-a2PtII) and six model nucleobases to an exceedingly stable entity.
Chem. Eur. J. 7, 1968-1980.

(41) M. S. Lüth, E. Freisinger & B. Lippert (2001).
Metal-modified nucleobase pairs and triplets as cytosine receptors.
Chem. Eur. J. 7, 2104-2113.

(40) X. Riera, A. Caubet, C. López, V. Moreno, E. Freisinger, M. Willermann & B. Lippert (2001).
Versatility in the mode of coordination [(C)-, (N,S), (C,N)- or (C,N,S)-] of the Schiff base: C6H5-CH=N-CH2-SEt to palladium(II). X-ray crystal structure of cis-[Pd{C6H5-CH=N-CH2-CH2-SEt}Cl2] and [Pd{C6H4-CH=N-CH2-CH2-SEt}Cl].
J. Organomet. Chem. 629, 97-108.

(39) W. Brüning, R. K. O. Sigel, E. Freisinger & B. Lippert (2001).
Pt(II) binding to N1 of cytosine: Strengthening the Watson-Crick pair with guanine, yet confining its pH existence range.
Angew. Chem. Int. Ed. Engl. 40, 3397-.

(38) E. Freisinger & B. Lippert (2001).
Relevance of alkali metal ions for the formation of thymine quartet structures: An X-ray study.
J. Inorg. Biochem. 86, 222.

(37) C. F. Moreno-Luque, E. Freisinger, B. Costisella, R. Griesser, J. Ochocki, B. Lippert & H. Sigel (2001).
Comparison of the acid-base properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) and some related compounds. Evidence for intramolecular hydrogen-bond formation in aqueous solution between (N1)H and the phosphonate group of 6Umpa2-.
J. Chem. Soc., Perkin Trans. 2 10, 2005-2011.

Publications 2000

(36) E. Freisinger, S. Meier & B. Lippert (2000).
Hydrogen bonding patterns of N(7) platinated guanine: Watson-Crick and different self-pairing motifs in a tris(9-methylguanine) complex of PtII.
J. Chem. Soc. Dalton Trans., 3274-3280.

(35) E. Freisinger, A. Schneider, M. Drumm, A. Hegmans, S. Meier & B. Lippert (2000).
Exocyclic oxygen atoms of platinated nucleobases as binding sites for alkali metal ions.
J. Chem. Soc. Dalton Trans., 3281-3287.

(34) R. K. O. Sigel, E. Freisinger & B. Lippert (2000).
Effects of N7-methylation, N7-platination, and C8-hydroxylation of guanine on H-bond formation with cytosine: platinum coordination strengthens the Watson-Crick pair.
J. Biol. Inorg. Chem. 5, 287-299.

(33) I. B. Rother, E. Freisinger, A. Erxleben & B. Lippert (2000).
trans-a2Pt(II) (a = NH3, CH3NH2) modified purine base pairs and triples: Hydrogen bonding between self-complementary pairs and triples and heterometal (Ag+) coordination leading to a 1 D helix.
Inorg. Chim. Acta 300, 339-352.

(32) R. D. Schnebeck, E. Freisinger & B. Lippert (2000).
Molecular architecture with 2,2'-bipyrazine and metal ions: Infinite loop and molecular square.
Eur. J. Inorg. Chem. 6, 1193-1200.

(31) J. A. R Navarro, E. Freisinger & B. Lippert (2000).
Self-assembly of palladium(II) and platinum(II) complexes of 2-hydroxypyrimidine to novel metallacalix[4]arenes. Receptor properties through multiple H-bonding interactions.
Inorg. Chem. 39, 2301-2305.

(30) J. A. R. Navarro, E. Freisinger & B. Lippert (2000).
From simple trans-[a2Pt(2-hydroxypyrimidine)2]2+ (a = NH3, CH3NH2) complexes to structures of higher complexity. Molecular recognition of 2-aminopyrimidine by hydrogen bond formation and reactivity toward additional metal ions.
Inorg. Chem. 39, 1059-1065.

(29) A. Schneider, E. Freisinger, B. Beck & B. Lippert (2000).
Ready formation of water-stable PtII-(µ-NH2)-PdII species through combination of trans-[(NH3)2PtIIL2]
(L = N,N '-heterocycle) and [enPd(H2O)2]2+.
J. Chem. Soc. Dalton Trans., 837-838.

(28) R. D. Schnebeck, E. Freisinger, F. Glahé & B. Lippert (2000).
Molecular architecture based on metal triangles derived from 2,2'-bipyrazine (Bpz) and enMII (M = Pt, Pd).
J. Am. Chem. Soc. 122, 1381-1390.

(27) J. A. R. Navarro, E. Freisinger & B. Lippert (2000).
[(Ethylenediamine)Pt(uracilate)]4 - A metal analogue of calix[4]arene: Coordination chemistry of its 1,3-alternate conformer towards first-row transition-metal ions.
Eur. J. Inorg. Chem. 1, 147-151.

Publications 1999

(26) A. Hegmans, E. Zangrando, E. Freisinger, F. Pichierri, L. Randaccio, C. Mealli, M. Gerdan, A. X. Trautwein & B. Lippert (1999).
Pt as mediator of strong antiferromagnetic coupling between two CuII ions in a heteronuclear CuIIPtIICuII complex of the model nucleobase 1-methylcytosinate.
Chem. Eur. J. 5, 3010-3018.

(25) S. Cosar, M. B. L. Janik, M. Flock, E. Freisinger, E. Farkas & B. Lippert (1999).
Mono- and di-nuclear complexes of (trpy)MII (M = Pd, Pt) with the model nucleobase 1-methylcytosine. Crystal structure and NMR solution studies.
J. Chem. Soc. Dalton Trans., 2329-2336.

(24) J. Müller, F. Glahé, E. Freisinger & B. Lippert (1999).
A major, pH-induced stereochemical switch of pairs of trans-oriented ligands in complexes of trans-a2PtII (a = NH3, CH3NH2).
Inorg. Chem. 38, 3160-3166.

(23) R.-D. Schnebeck, E. Freisinger & B. Lippert (1999).
Anion pore structure through packing of molecular triangles.
Chem. Commun., 675-676.

(22) R. K. O. Sigel, M. Sabat, E. Freisinger, A. Mower & B. Lippert (1999).
Metal-modified base pairs involving different donor sites of purine nucleobases: trans-[a2Pt(7,9-DimeG-N1)(9-EtGH-N7)]2+ and trans-[a2Pt(7,9-DimeG-N1)(9-EtG-N7)]+ (a = NH3 or CH3NH2; 9-EtGH = 9-ethylguanine; 7,9-DimeG = 7,9-dimethylguanine). Possible relevance to metalated DNA triplex structures.
Inorg. Chem. 38, 1481-1490.

(21) M. B. L. Janik, A. Hegmans, E. Freisinger & B. Lippert (1999).
Reactivity of an extremely sterically crowded monofunctional Pt complex, [Pt(1-MeC-N3)3(H2O)]2+ (1-MeC = 1-methylcytosine), toward model nucleobases and selectivity toward guanine in single- and double-stranded deoxyoligonucleotides.
J. Biol. Inorg. Chem. 4, 130-139.

(20) F. Zamora, H. Witkowski, E. Freisinger, J. Müller, B. Thormann, A. Albinati & B. Lippert (1999).
Crystal structures of a protonated form of trans-[Pt(NH3)2(mura)2] and of a derivative containing three different metal ions, Pt2+, Ag+, and Na+ (mura = 1-methyluracil). Major difference in packing between heteronuclear pyrimidine nucleobase complexes of cis- and trans-(NH3)2PtII.
J. Chem. Soc. Dalton Trans., 175-182.

(19) J. A. R. Navarro, M. B. L. Janik, E. Freisinger & B. Lippert (1999).
[(Ethylendiamine)Pt(uracilate)]4, a metal analogue of calix[4]arene. Coordination and anion host-guest chemistry related to its conformational dynamics.
Inorg. Chem. 38, 426-432.

(18) R.-D. Schnebeck, E. Freisinger & B. Lippert (1999).
A novel highly charged (+12) anion receptor that encapsulates simultaneously NO3¯ and PF6¯ ions.
Angew. Chem. Int. Edit. 38, 168-171.

(17) R. K. O. Sigel, S. M. Thompson, E. Freisinger & B. Lippert (1999).
Combining four different model nucleobases (uracil, adenine, guanine, cytosine) via metal binding and H bond formation in a single compound.
Chem. Commun., 19-20.

(16) R. K. O. Sigel, E. Freisinger & B. Lippert (1999).
Towards cationic di- and trinucleotide analogs with a platinum(II) backbone.
J. Inorg. Biochem. 74, 296.
Poster Presentation; ICBIC-9, Minneapolis, USA, July 11-16, 1999.

(15) M. Drumm, E. Freisinger, M. S. Lüth, E. Sletten & B. Lippert (1999).
Structural characterization of short oligonucleotides modified with trans-a2Pt(II) by NMR.
J. Inorg. Biochem. 74, 119.
Poster Presentation; ICBIC-9, Minneapolis, USA, July 11-16, 1999.

Publications 1998

(14) R. K. O. Sigel, E. Freisinger, S. Metzger & B. Lippert (1998).
Metalated nucleobase quartets: Dimerization of a metal-modified guanine, cytosine pair of trans-(NH3)2PtII and formation of CH···N hydrogen bonds.
J. Am. Chem. Soc. 120, 12000-12007.

(13) A. Schimanski, E. Freisinger, A. Erxleben & B. Lippert (1998).
Interactions between [AuX4]¯ (X = Cl, CN) and cytosine and guanine model nucleobases: Salt formation with (hemi-) protonated bases, coordination, and oxidative degradation of guanine.
Inorg. Chim. Acta 283, 223-232.

(12) M. S. Lüth, E. Freisinger, F. Glahé & B. Lippert (1998).
Mixed adenine, guanine nucleobase quartets: Metal-modified forms of an open U and a closed rectangle.
Inorg. Chem. 37, 5044-5045.

(11) A. Hegmans, M. Sabat, I. Baxter, E. Freisinger & B. Lippert (1998).
Synthetic ways to tris(nucleobase) complexes derived from cis-diammineplatinum(II) and a platinum(II) complex containig four different ligands, three of which are nucleobases.
Inorg. Chem. 37, 4921-4928.

(10) A. Hegmans, E. Freisinger, E. Zangrando, A. Ashfar, E. Hübener, T. G. Appleton & B. Lippert (1998).
Tri- and tetrakis(1-methylcytosine) complexes of PtII: Syntheses and X-ray structures of [Pt(1-MeC-N3)3Cl]+ and [Pt(1-MeC-N3)4]2+ compounds.
Inorg. Chim. Acta 279, 152-158.

(9) B. Lippert, P. Amo-Ochoa, W. Brüning, E. Freisinger, M. S. Lüth, S. Meier, C. Meiser, S. Metzger, H. Rauter, A. Schreiber, R. K. O. Sigel & H. Witkowski (1998).
Creating regular arrangements of nucleobases through metal ion coordination and H bond formation.
Pure & Appl. Chem. 70, 977-983.

(8) M. S. Lüth, E. Freisinger, F. Glahé, J. Müller & B. Lippert (1998).
Taking advantage of right angles in N1,N7-diplatinated purine nucleobases: Toward molecular squares, rectangles, and meanders.
Inorg. Chem. 37, 3195-3203.

(7) C. Meiser, E. Freisinger & B. Lippert (1998).
Dimerization of metalated nucleobase pairs via hydrogen-bond formation: Open metalated base quartets of mixed adenine-N3, guanine-N7 complexes of trans-(NH3)2PtII with two different guanine-guanine pairing schemes.
J. Chem. Soc. Dalton Trans., 2059-2064.

(6) J. Müller, E. Zangrando, N. Pahlke, E. Freisinger, L. Randaccio & B. Lippert (1998).
Affinity of the iminooxo tautomer anion of 1-methylcytosine in trans-[Pt(NH3)2(1-MeC-N4)2]2+ for heterometals.
Chem. Eur. J. 4, 397-405.

(5) R. K. O. Sigel, E. Freisinger & B. Lippert (1998).
If Watson-Crick and Hoogsteen sites of guanine are blocked, hydrogen bonding with cytosine is via N2 and N3.
Chem. Commun., 219-220.

Publications 1997

(4) M. Peilert, S. Weissbach, E. Freisinger, V. I. Korsunsky & B. Lippert (1997).
+3 Oxidation state of platinum in dinuclear complexes with thymine nucleobases: Structural and solution studies.
Inorg. Chim. Acta 265, 187-195.

(3) H. Rauter, I. Mutikainen, M. Blomberg, C. J. L. Lock, P. Amo-Ochoa, E. Freisinger, L. Randaccio, E. Zangrando, E. Chiarparin & B. Lippert (1997).
Cyclic metal complexes of nucleobases and other heterocycles: Molecular boxes, rectangles, and hexagons.
Angew. Chem. Int. Edit. 36, 1296-1301.

(2) H. Witkowski, E. Freisinger & B. Lippert (1997).
Uracil quartet formation through non-covalent interaction with a neutral metal ammine complex.
Chem. Commun., 1315-1316.

(1) C. Meiser, B. Song, E. Freisinger, M. Peilert, H. Sigel & B. Lippert (1997).
The N3 position of N9-substituted adenine as a metal ion binding site: Structural and solution studies with PdII and PtII complexes of N6',N6',N9-trimethyladenine.
Chem. Eur. J. 3, 388-398.